![]() This allowed us to evaluate potential differences among first-line treatments for EGFRm + NSCLC patients with BMs and provide a useful reference source for effective future clinical applications. The patients may or may not have received brain radiotherapy. ![]() In this real-world clinical study, systemic and local treatment outcomes of patients with BMs were retrospectively analyzed focusing on EGFRm + NSCLC combined with BMs cases and included 1st generation EGFR-TKI treatment alone and 1st generation EGFR-TKI plus chemotherapy or anti-angiogenesis drugs. Therefore, the best first-line therapy for EGFRm + NSCLC with BMs has yet to be unequivocally established. It is noteworthy that most NSCLC patients with BMs are not usually included in clinical trials. Although third-generation tyrosine kinase inhibitors (TKIs) that target EGFR have enhanced central nervous system (CNS) permeability and show better CNS efficacy in patients compared to first-generation EGFR-TKIs, the limited treatment options after drug resistance highlights the urgent need for alternative treatment strategies for patients with BMs. The percentage of patients diagnosed with advanced NSCLC and BMs is about 25–30% on first diagnosis and a further 40–50% develop BMs during the subsequent course of the disease. About 70% of EGFRm+ NSCLC patients develop brain metastases (BMs), compared to an incidence of 38% of NSCLC cases without an EGFR wild-type mutation. According to the PIONEER study, from 372 Chinese NSLC EGFRm + patients, 346 had EGFR activating mutations, with 182 exon 19 deletions and 169 L858R point mutations being the most common mutation types. In China the prevalence of EGFRm + NSCLC cases has been estimated to be 36.5–40.3%. Epidermal growth factor receptor ( EGFR) mutations, are known oncogenic drivers in NSCLC patients and east Asian individuals with NSCLC had a substantially greater EGFR mutant (m +) prevalence than Caucasian patients (about 30% vs. Non-small cell lung cancer (NSCLC) patients have unacceptable morbidity and mortality rates, with only 15% surviving for up to 5 years after diagnosis. The therapy improved the control and delayed progression of intracranial lesions and prolonged survival times. Conclusionsįirst-generation EGFR-TKI + bevacizumab treatment outperformed other regimens in EGFRm + NSCLC patients with brain metastasis. Most patients suffered grade 1–2 treatment-related adverse events, which were relieved soon after symptomatic treatment. Significant difference was found in intracranial ORR between groups A + B vs. Median OS in groups A and B were 27.9 m and 24.4 m, respectively, while groups C and D have not yet achieved median OS. Extracranial PFS were longer in group B in comparison with group A (13.0 m vs. Intracranial PFS of groups C + D was longer than for groups A + B (18.9 m vs. Intracranial and extracranial progression-free survival (PFS), the overall survival (OS), objective remission rates (ORRs) and adverse events were analyzed. In this retrospective study, 172 EGFRm + patients with advanced NSCLC who received a 1st generation EGFR tyrosine kinase inhibitor (TKI) were divided into 4 groups: A, EGFR-TKI (n = 84) B, EGFR-TKI + pemetrexed + cisplatin/carboplatin chemotherapy (CT) (n = 55) C, EGFR-TKI + bevacizumab (n = 15) and D, EGFR-TKI + pemetrexed + cisplatin/carboplatin CT + bevacizumab (n = 18). The aims of the study were to evaluate potential differences among first-line treatment for EGFR mutant (m+) non-small cell lung cancer (NSCLC) patients with brain metastasis in China and to identify the factors influencing survival outcomes.
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![]() The GUI needs significant work, and I wish it offered a few more options for step rates– to say nothing of making it AS-native. BreakTweaker’s MicroEdit features which are the star of the show, offering a super-fun exploration of unique rhythms, blurring the boundary between rhythm and pitch. Even just going through the factory content, including the expansion packs, is a wonderful listening and learning experience. A drum machine is not in iZotope’s wheelhouse but this drum machine is so clever and flexible. Of the three on the chopping block, BreakTweaker is the most understandable, but the most heart-breaking. There’s a pretty hefty to-do list to make it a proper modern synth. that it is probably not worth it for iZotope to invest in development to chase a tiny slice of that market. However, there are so many options for distortion/overdrive/harmonics/color/etc. Trash 2 is probably the most in-line with the signal processing purpose of iZotope’s product line. Some developers let their products rot on the vine while continuing to sell them, so it’s right for them to make the clear decision. ![]() iZotope either needed to give these plugs some attention or stop asking for money for them. I have all three products and have used them all to varying degrees. The news follows the 2021 announcement that Native Instruments and iZotope were partnering to create a new technology group, now known as Soundwide and Native’s announcement last month that they were retiring Absynth.įor more information, see the FAQ on the iZotope site. In explaining the reasoning for their decision, iZotope said “We occasionally need to retire older products in order to focus our resources and development efforts on building new, innovative products and features.” Support will remain in effect for 12 months from your date of purchase. The products are no longer available for purchase on the company’s site. They called it “the ultimate distortion plug-in for any instrument.”
![]() ![]() Pair your Shadowblade with a defensive Knight or Fighter to distract your enemies towards your partners and then deal damage from afar. An extra 4 ability points for 8 more slots of utility sounds like a good deal if youre already heading that way. Shadowblades will not do a high amount of damage in a single hit, but the longer they stay alive, the more useful they become. Thats a good build, Chumsie, but you could probably even go for Rank 2 in Witchcraft and Aerothurge for an additional 2 Novice and 2 Adept skills and look for some bonuses to INT to make them usable.They specialize in Scoundrel and Polymorph as their Combat Abilities and Thievery as their Civic Ability. Characteristics The shadowblade primarily focuses on Finesse and Wits as their primary attributes. I don't think any of the other ones scale with anything in particular as I said, they're mostly utility skills. Flay Skin and Tentacle Lash scale with STR, so just keep that in mind. There are skills to fit into any type of build. ) Seriously: Polymorph is the ultimate utility school. You'd want to use this class members to sneak in for a first strike and then quickly retreat behind other party members to support them or use magic attacks from a distance. The Shadowblade is a hybrid melee and magic class in Divinity: Original Sin 2. 1 comment Best Pick the Shadowblade preset.The academy had a prized pupil, and the Shadowblade has found that hunting Sorcerers satisfied the soul better than picking pockets. Throwing Knife A decent ranged skill for this Build (85 damage vs basic attack). Shadow Blade is also going to use your concentration as well. Few things to consider: 1) Shadow Blade and Shillelagh are both bonus action casting times so you will need 2 turns to get them both active. Here the most elite secrets of magic were offered freely, and the Shadowblade perfected them all.īy the time the ruse was discovered, it was too late. Here’s how to create an effective ‘single target’ Rogue build: Puncture Enhanced Puncture Fundamental Puncture. Location: Kent Join Date: Posts: 1,233 Its not impossible to do it, just a character decision if it is wise. ![]() Posing as the child of nobleman, it was almost easy to gain access to the Academy of the Source Hunters. (2017) Divinity Original Sin 2 Rogue & Shadowblade starting build and how to level for Fort Joy & Hollow Marshes. The fleet-footed Shadowblade escaped, but the rest of the village did not.Īs a wandering orphan, thieves, beggars, pirates, and murderers taught the Shadowblade that man was no more than a beast, and the laws of nature were simple: Kill or be killed eat or go hungry.īut a survivor among survivors needed an advantage. 1 wulfster42 6:18pm Honestly sounds like a good combo for a lone wolf tbh, as youll have more max vitality, higher damage, and plenty of points to get 6-10 necromancy for the life drain, while still maxing scoundrel. "A powerful assassin whose arsenal of both daggers and magic would terrify any enemy, if they ever saw it coming."When the Sorcerer went mad, only those who could flee were spared a terrible death. This page features the builds created by Castielle on youtube, you can find detailed written build guides here. Shadowblade is a preset class in Divinity: Original Sin II. Updated: 10:00 Builds for Divinity: Original Sin 2 are player-created combinations of skills and gear to adhere to a specific theme or reach a min-max objective. ![]() In my play-through I got the Resistance communications next followed by power (in the 3rd row, below). You still want the GTS first in order to get the 5th squad member ASAP and also to allow training of rookies as soldiers (which then allows them to go on Resistance Ring missions). The Infirmary is useful, but with care you won’t need the healing boost (you can always scan at the Templar HQ for a healing buff in a pinch) and if you rotate your troops you won’t need to remove negative perks either. The Training Centre is brilliant, but you won’t have the AP to use it initially. You always want to keep an engineer stationed in the Ring to reduce mission times. So missions to contact the other resistance factions and ones to track down the Chosen. Generally, you want to work on the missions that give you more resistance slots first. ![]() The same applied to my main Ranger and with Run&Gun and Reaper he could clear the screen of hostiles. I stacked lots of +Mobility missions on my Reaper and she was a fantastic scout. It makes it a lot easier to keep a deep bench and if you’re careful with the bonuses you can get some great super-soldiers. Promotions, bonuses to stats and more mobility all make a huge difference. Each participant in resistance missions gets XP but more importantly they can get bonus benefits too. Once you’ve got the Ring upgraded and few bonded troops, you never have to worry about the Doom clock again. New resources, new faction slots, bonuses to research, new upgrades, Chosen base locations and (even better) reductions in the Avatar doom counter. This allows you to send small groups of troops out on “side-missions” between the main XCOM tactical deployments and are fantastic on several levels.įirst, you get great strategic-level things. The key new building is the Resistance Ring. The AWC is gone and it’s benefits are spread out among the new additions. So wait to the last possible moment before taking them out. Second, each time you kill them you get bonus XCOM Ability points and if you’re doubling them (which you should) that nets you a sweet 10 points a time. First, they’re quite hard with basic equipment due to the nature of the special base mission (killing stuff fast is key). You want to work out their locations ASAP (as it unlocks more mission slots at the Ring) but then don’t go to kill them early. Using the Resistance Ring you can work out their base location to kill each of them for good but don’t go straight away. These are randomised, so if you’re going to an area where the Warlock hangs out and he’s weak to explosives and Templars, make sure you bring the wannabe Junk-Rats and Psi-Jedis. The key thing generally is to utilise their weaknesses. After a few of these, Jaworksi is basically Neo. Spreading out and/or having abilities to see cloaked units helps loads though. She does hit-and-run tactics so you have to be very careful about triggering more pods while chasing her. Because she does come to you though you can clear the initial area out and wait for her. ![]() The Assassin is more troublesome as she’ll come straight at you, can’t miss and will stun several characters at once. They get more dangerous as you get close but they’ll stay away generally and you can pick the time you want to engage. The Hunter and Warlock will try and stay at range and their abilities are not insurmountable (zoning areas out and summoning walking bombs, respectively). They’re aren’t many specific tricks to thwarting them you just want to deal with them away from the other Advent forces. Bladestorm Vs The Lost, or “Bringing Teeth to a Sword Fight” While this is nominally to do with helping their bosses it’s probably more to ensure a captive audience to their moustache-twiddling monologues (which even Bradford comments as being excessive). This allows them to stage a base assault and capture you (the player). Though they can cause quite a bit of damage, their aim is to capture soldiers to build up knowledge of where your base is. If you do any missions in their territory, they can hop in (randomly) and try and ruin your day. The three of them each have unique abilities and each have one third of the world under their control. Let’s start with them, as they’re the headlining band. That said, the new toys you’re given provides even more cool ways to pummel aliens, so why wouldn’t you use them?Īnd the Chosen themselves? They can interfere with your awesome plans and ruin your day. It’s still XCOM though and if you follow the tips for Legendary here you won’t go far wrong. The new XCOM 2 expansion is fantastic, expanding most areas of the game and providing loads more ways to play it. ![]() ![]() Move all the fruit into the left basket, then climb into the funnel on the right Budoir. Move the lever on the left wall to stop the green fruit from appearing. Pull the belt out of the machine and then wait - you will end up going back to the first area. Take the second wrench and use it to undo the final nut. Pull the disc out and put it back in again, then press button 2. Take the wrench from the robot that appears and use it to undo 3 of the 4 nuts on the large machine to the right. Put the silver disc on a string into the machine, and press button 1. Go across and out through the top right hole. Now turn the big wheel to lower the water level. ![]() In the next room, turn the 3 small handles until the red tips are pointing directly up and down. Pull the flush lever again and turn a second (lower) valve. Pull the flush lever and quickly turn the valve when the water is low enough. Go back to the left and down the manhole Sewers. Ignore it, and take the flashlight from the wall. Head into the passage to the right to see one of the creatures that captured your dog. After the fridge vibrates out of the way, take the hook and attach it to the manhole cover climb down but it is too dark to see anything. Plug this into the powerpoint on the wall, then click on the cable on the floor and plug this in. Click on this hole twice and a double adapter will fall down. Open the fridge and a mouse will run up to the hole in the ceiling. After it gets caught by the spider, click on the fly again to swing out of the area Pantry. Click on the fly to move it up to the vomit on the pipe, then click on yourself to shake it free. Now wait for this insect to crawl up higher and click on the possum so that it gets eaten (this requires timing). Remove the small rock that is blocking the path of the crawling insect. Walk right on the large pipe and it will break a fly will appear and land over on the left. When the right creature falls asleep, take his hammer.īack at the previous screen, hit the robot on the head and you will climb down the ladder Pit. Turn the tap beneath the pot, then turn the tap outside. Click the large lever just left of the house twice to pump water into the pot. Look outside to the right and click on the small creature twice so that it shakes pollen into the funnel, then down into the pot. Back in the house, turn the right handle to adjust a funnel on top of the house (so it points more to the right). Look at the two creatures on the branch on the left click on the small one followed by the large one, then while the large one is distracted, fill the hole with the cork. Open all three bottles, and pick up the large cork that ends up on the floor. Walk to the far left Snailman.Įnter the round house. PoklopĬlick on your character in your space ship, then click on the green bug and put it on the branch that is trapping you. Click on your dog's kennel and he will be stolen Hatch. Samorost 3 Walkthrough continues on with Chapter 6: Explosion & Totem Puzzle.Watch as the aliens land near your lighthouse Intro. To solve the puzzle you need to combine all three types of plants. Grow an onion out of fruits (apple, cactus fruit, corn cob)įruits Note: You can see how to obtain the green fruit (at 1:20), how to obtain the other two fruits (at 3:07) is just a combination of the apple and the green fruit.* Note: The tunnel colors are barely visible for in-game, which makes the puzzle seem harder than it is. – If this sounds to complex just copy the correct position out of the video. You need to change the different lever so that in the end only one color will be visible and the last lever will then move to this specific chamber. You can see lights are going on an off in the chamber to the bottom left, that will indicate how the different tunnels change the last lever. Termite Underground Tunnel maze puzzle solution: Depending on the tunnels you choose (3 colors that are matching the chambers below*) the silk ball will land in a different spot. Solve the Termite Underground Tunnel puzzle.Chapter 2: Into Space & Bubble PuzzleĬhapter 4: Floating Wood & Termite Underground Tunnel Puzzle Protip: Do you want to find all SECRETS and Achievements in Samorost 3?Ĭheck out our “ Samorost 3 Achievements Guide” page. Additional Notes: Mouse recommended Chapter 1: Beginning & Paper Puzzleįuro will be your puzzle-solving guide showing you around the game’s five planets and four moons. ![]() However, due to the increase in demand for multi-drop vehicles we have teamed up with Towergate Insurance to provide a 12 month contract with a. If.Īt Kendall Cars we have not been able to provide insurance cover for driver's that wish to use our vehicles for courier work on our normal rental insurance policy. Grava Chrysler Jeep Dodge 29 Mystic Avenue, Medford, MA 02155 0 miles away. NEW SOUTH FULHAM CLEAN AIR NEIGHBOURHOOD – there is a new Clean Air Neighbourhood being introduced to the west of Wandsworth Bridge Road, London, SW6. Off-airport rental car locations in Santiago de los Caballeros are around 40. We would like to help advise our customers on the most common contraventions - so that you can plan your journey and try to avoid these additional costs: ![]() UPDATED: How to avoid those Penalty Charges. We have launched a new product for all our customers to provide peace of mind when renting from us. boulder free stufffor sale by owner lubbockhouses for rent near me craiglist 2015. with our new CDW (Collision Damage Waiver) product that not only reduces the insurance excess, but also waivers the risk of paying for loss of use (LOU) if a fault accident. Cheap 6 passenger van rentals in Homestead. There’s also the same trademark MG practicality and. Take advantage of up to 273 miles* of electric range, rapid charging and a host of intelligent features as standard. ![]() Do you need a special license to drive a 15-passenger van rental No, the 15-passenger vans do not require a special license. We have convenient locations all over the United States. Type in your location to find an Avis near you. book yours today! Click here for further info. Where can I rent a 15-passenger van Renting a 15-passenger van is easy, just start by filling out the form above. Here we start our journey to an electrified fleet. We now have the NEW Electric MG ZS on fleet. It is only a 6 minutes taxi from the main Train station or a short walk from the town. If you are traveling and need a van for a family vacation or a school trip, SIXT makes it easy to get a great price when you rent a 12 or 15 passenger van. Enterprise 12 passenger van rental, get great prices on 12-15 passenger van rentals through 12/31/22. Valid on Economy Cars and up at participating US locations, blackouts may apply. Get 5 or off your next rental at Payless Rent A Car. Our 13th branch is now open! The Basingstoke branch provides a good selection of our fleet range, but due to location size it is restricted on the the larger trucks. Payless 12 passenger van discount, get 5 off your next rental by 9/30/23. ![]() Only answer when you are 100% sure of the correct answer. Sing the note and work out the way up or down to the tonic. Use the repeat button as often as needed. Here are 3 more practice approaches that really helped me a lot.ġ) Think about each quiz. Bonus Strategies for All Your Functional Ear Training It’ll give you a fighting chance and, when you get better and better results, will improve your motivation for even more practice sessions. compare the tritone (Fi) to either the 4th or the 5th.Īll those individual practice sessions will pay off big time when you go for the complete chromatic scale.Practice the following pairs individually: Here, in this screenshot you can see that I’ve added the minor 3rd to the major scale. Instead of overloading your ears go for one! chromatic note at a time. 1) Add 1 Chromatic Note to the Major Scale You could be in the key of Eb and hear that 4th degree sound and therefore it has to be an Ab note – yet when you are in the key of C, that same 4th degree characteristic sound lets you know you’ve just heard an F. It’s a certain characteristic that’s independent from the actual pitch – meaning, it doesn’t matter what key it’s in. the 3rd degree and the 4th degree of the scale. You’ll start to notice the difference in sound between e.g. It won’t take long until you’ll start to hear that “personality” sound I’ve been referring to. And don’t worry if you are somewhat guessing at first and you go by a sense of high- or lowness when answering the questions. ![]() With only 4 notes it’s faster to tune into each note’s “personality” and get a feel for the sound. A fancy term for those 4 notes is: lower tetrachord ![]() ![]() Com Best Premium SSH for SSL/TLS, ssh websocket, Free V2ray Server. SG 5 Jupiter Host .id Server Singapura OpenSSH/Dropbear 22, 44, 77 SSL/TLS 222, 444, 777 Websocket HTTP 2082, 80, 8880 Websocket HTTPS 443 Bad VPN UDPGW 7100,7200,7300 Custom Host .my.id CDN CF. The credit balance is charged every 1 Monthh for an active VPN Tunnel Account. All Servers SSH Websocket Multiple studies claim drinking water boosts metabolism by 24-30%. But this may also vary from person to person. Our research also found that green tea and oolong are particularly helpful in increasing fat oxidation, which helps burn more calories when exercising. Tea contains catechins, a health-boosting compound that works hand in hand with caffeine to increase your metabolic rate, thus boosting metabolism to promote weight loss. However, this may vary depending on age and body weight. Studies also show that caffeine aids in fat loss by boosting performance and endurance during a strength training exercise. This can be backed by multiple studies that discovered that people who consume three cups of coffee burn an extra 100 calories daily. CoffeeĬaffeine is another metabolism booster. ![]() The results showed a significant reduction in the consumption of calories. The same was proven by a study that subjected over 200 people to the chemical. ![]() What's more? Capsaicin also has appetite-reducing properties. Spices that help lose belly fat like chili peppers have capsaicin, a mineral that boosts metabolism by increasing the rate of calories your body burns.Įxperts studying the subject found that capsaicin enhances metabolism. Needless to say, a diet low in iron or selenium reduces the thyroid’s ability, therefore slowing down metabolism. Mineral iron and selenium-rich foods such as meat, legumes, seafood, nuts, and seeds are essential for the proper functioning of the thyroid gland, which, as we’ve seen, regulates metabolism. Related: High Protein Vegetables for Bodybuilding 2. In addition, proteins keep you satisfied for longer and prevent overeating. Statistically, proteins boost metabolic rate by 15-30%, fats by 0-3%, and carbs by 5-10%. Studies show that proteins increase TEF significantly compared to other foods. ![]() ![]() Proteins like lean meat, dairy, eggs, and fish generally have a high thermic effect on food (TEF).Ī high TEF means that your body burns more calories when digesting proteins than, say, carbs. Why proteins? Because the human body needs more energy to digest foods rich in protein. To boost metabolism, make sure to include foods such as eggs, meat, dairy, legumes, nuts, and seeds. High protein meals for muscle gain are the go-to foods when it comes to boosting metabolism. Other metabolism-boosting options include lean proteins, whole grains, fruits, vegetables, and healthy fats like avocados and nuts.īy making these foods a regular part of your diet, you can support your body's fat-burning processes and achieve your weight loss goals more effectively. Incorporating these nutrient-dense options into your diet can help rev up your metabolic rate, allowing your body to efficiently burn calories and shed unwanted pounds.įrom spicy peppers that contain capsaicin, known for its thermogenic properties, to green tea, which is rich in catechins that promote fat oxidation, these foods can give your weight loss efforts an extra edge. If you're looking to increase your metabolism to lose weight and promote fat burning, fill your kitchen with these 11 metabolism boosting foods. ![]() Second observation record of the break deck (Operation Diary) Observation record of the forward galley (Operation Diary)įirst observation record of the recreation deck (Operation Diary) Information from the ship's black box (Operation Diary) Information about escape pods (Operation Diary) Voice recording of the scanning room (Operation Diary) Recording of Keane's address to the crew members (Aurora) Record of additional tasks of operation (Alterra) The third magazine of Bart Torgal (Degazy) The first magazine of Bart Torgal (Degazy) Opens all doors on the Aurora, as well as protective fields in the basesĭisables damage from creatures and the environment (to both the player and vehicles). Removes all terrain around the player in a circle with a diameter of # meters (maximum value is 100) Spawns several air bubbles around the player Repairs all Cyclopes on the map (except destroyed ones) Makes holes inside all Cyclops on the map You can use the team only in Survival and Hardcore modesĮnables longer underwater time and adds a decompression sickness factor if not taken care ofĮliminates all radiation leaks in the Aurora Reactor Bay Infinite energy for vehicles, tools and base The use of the Fabricator, Builder, Vehicle Assembler, Vehicle Modification Station and Modification Station becomes free Speed up the construction of buildings with the Builder Reduces water filtration time by the Water Treatment PlantĮggs hatch very quickly after being placed in the Large Aquarium Gives out resources for crafting the selected item Also gives the player items in the inventory (Builder, Welding Machine, Knife and Scanner). Gives the player resources and tools (Knife, Builder, 3x Batteries, 4x Computer Chips, 5x Algae Samples, 10x Titanium and 10x Glass). Gives the player tools (Welding Machine, Sea Glider, Flare, DNA Transmitter, Propulsion Gun, Stasis Rifle). Spawns resources (Quartz, Copper Ore, Silver Ore, Salt, Gold and 4x Scrap Metal) Gives the player all of the Exosuit's hand upgrades. Gives the player all Exosuit Upgrade Modules Gives the player all Moth Upgrade Modules The player is teleported into it automatically. In such a situation, you need to click on F3 2 times.Īdds the specified number of items to inventoryĬreate items (will appear in front of the player)Įscape Pod 5 spawns. Sometimes the console does not start after restarting, although it previously functioned. Right-click on the value and select " Change".Find value UWE.DisableConsole_h3091019503.Follow the path HKEY_CURRENT_USER > Software > Unknown Worlds > Subnautica.Run the file of the same name with administrator rights.If the console does not unlock even after minimizing, it remains to follow this instruction: Uncheck the box next to Disable Console.Minimize game via keyboard shortcut Alt + Tab.In pirated copies, the above method may not work, so you need to: If the mouse cursor jumps, it is recommended hold left button mice on the window uncheck. To turn on the console, press the keys F3 и F9, and then uncheck the box next to the inscription Disable Console. To open the console, you must click on the button tilde (~), which on the Cyrillic keyboard is designated as the letter “ Ё".īy default, the space for entering commands is inactive. Through it, you can spawn items, create creatures and plants, build various objects, make improvements and much more. Codes for Subnautica entered in the console. |
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